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Also known as histamine H2-receptor antagonists (H2RAs), these are used to treat duodenal ulcers and gastric ulcers and can reduce circulating B12 concentrations with prolonged use

That's why the first question shouldn't be, Which one is best? The better question is, Which one best matches what I'm dealing with right now? Start with your actual symptom pattern If your depression shows up with constant worry, physical tension, overthinking, and trouble settling down, that points the conversation in one direction

While we cant yet prescribe specific bacterial cocktails for B12 optimization, understanding this connection helps explain why some people need way higher doses despite similar starting points

These can include pain at the injection site, mild diarrhea, or an allergic reaction